Overweight and those who have big thighs will likely to face these problems. Using elastic bandages around the portion of legs that rub may help. Be sure the elastic bandage is secure so it does not move across the skin.
Home made lubricant can be made by mixing one cup each of A & D ointment and Vaseline. In that add one fourth cup each of vitamin E cream and aloe Vera cream to have better consistency and good smell. This ointment works great on your skin and helps in healing and prevention of blister.
When you need cures, the natural ways is the best way to go. Vitamins do offer benefits. For instance, vitamin A helps to treat skin problems. The benefits are not only can you treat chafing; you can also use vitamin A to treat acne, improve night vision, and treat acute infections. Vitamin A will help protect your body from cell productions that become effected by toxic chemicals. If you purchase vitamin A with beta-carotene, it provides you with a strong antioxidant to help protect you from certain cancers, such as lung and skin cancer. Smokers can benefit from vitamin A also, since it will treat chafing conditions, as well it will make a great supplement solutions for fighting cancer.
Most importantly you must keep yourself dry. Many times people experience chafing because the skin between their body parts has become moist due to sweating, because of this many people experience chafing during the hot summer months so there are several things you must do. Make sure that you keep your entire body as dry as possible. Make sure that you always wear one hundred percent cotton clothing and always drink plenty of water.
However, the most important way for you to remain dry and keep from experiencing chafing is to apply talcum powder to your inner thighs and anywhere else you experience chafing at.
The key to prevent chafing is to avoid sweating and friction between body parts. To do this try to keep yourself dry, put proper clothes; try to wear hundred percent cotton clothes etc. Try to stay hydrated by drinking plenty of water. This will allow you to perspire freely. Use talcum powder to stay dry. Always wear clean and dry clothes Use petroleum-free and non-staining lubrication to prevent friction while walking, jogging or exercising. You can also use it on your feet, toes etc to avoid blisters.
Apply some A+D ointment to the dry/chafed areas -- it should clear up in about a day. Be sure to cover up affected areas with BodyGlide or Vaseline before you head out for a run.
The best treatment for chafing is prevention, but if it happens anyway, the first thing you should do is get checked to see if a fungus is responsible.  Treat the fungus, but don't be surprised if the skin problems persist.  After the anti fungal treatment from the doctor, use a combination zinc oxide and anti fungal until it is reasonably dried out.  After that, do maintenance with an ointment with polygonum extract.  This should have some alcohol in it, and not be too oily.  The slickness comes from the polygonum.